Clinical Studies

Clinical research is very important because it is one of the best ways to improve patient care. Currently, hundreds of studies are taking place throughout Lurie Children's, including at the research institute, that involve many of our doctors, nurses, clinical research professionals, scientists and technicians.

Search below for a clinical study, or read more on our guide to clinical research for parents and children.

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Studies

IMPAACT P1115 Very Early Intensive Treatment of HIV-Infected Infants to Achieve HIV Remission

IMPAACT P1115 will explore the effects of early intensive antiretroviral therapy (ART) on achieving HIV remission (HIV RNA below the limit of detection of the assay) among HIV-infected infants.

BIOPIC: Fungal Biomakers for Diagnosis and Response to Therapy for Pediatric Candidemia

ClinicalTrials.gov ID: NCT 02220790

This study will create an international multi-center cohort of children with new clinical concern for infecton while in the hospital.  Sites used are part of the International Pediatric Fungal Network (ipfn.org).  The study plans to prospectively enroll pediatric patients at high-risk of developing invasve candidiasis over a four year...

INFUSE Bone Graft (recombinant human Bone Morphogenetic Protein-2/absorable collegen sponge) in the treatment of Tibial Psudarthrosis in Neurofibromatosis 1 (NF1)

ClinicalTrials.gov ID: NCT02718131

The current study proposes adding BMP-2 (INFUSE), an anabolic agent, at the surgical site of TPA repair in children with NF1, compared to a control group of patients treated surgically without BMP-2. The following Specific Aims will be addressed: 1) to determine if use of an osteogenic agent (BMP-2) at the time of surgical repair of TPA in NF1...

Evaluating the Safety and Pharmacokinetics of VRC01, A Potent Anti-HIV Neutralizing Monoclonal Antibody, in HIV-1 Exposed Infants

ClinicalTrials.gov ID: NCT02256631

VRC01 and VRC01LS are anti-HIV neutralizing monoclonal antibodies that may help prevent mother-to-child transmission of HIV. This study will enroll HIV-infected mothers who are at increased risk of passing HIV on to their children. The purpose of this study is to assess the safety and PK of VRC01 and VRC01LS in HIV-exposed infants. This study will...

Evaluating the Infectivity, Safety, and Immunogenicity of the Recombinant Live-Attenuated Respiratory Syncytial Virus Vaccines RSV ΔNS2/Δ1313/I1314L or RSV 276 in RSV-Seronegative Infants 6 to 24 Months of Age

ClinicalTrials.gov ID: NCT03227029

The purpose of this study is to evaluate the infectivity, safety, and immunogenicity of the recombinant live-attenuated respiratory syncytial virus (RSV) vaccines RSV ΔNS2/Δ1313/I1314L or RSV 276 or placebo when delivered as nose drops to RSV-seronegative infants 6 to 24 months of age. This study is a companion study to CIR 321.