Clinical Studies

Clinical research is very important because it is one of the best ways to improve patient care. Currently, hundreds of studies are taking place throughout Lurie Children's, including at the research institute, that involve many of our doctors, nurses, clinical research professionals, scientists and technicians.

Search below for a clinical study, or to see a more comprehensive listing of the clinical studies taking place at Lurie Children's, please use our link to the ClinicalTrials.gov website.

You can learn more about the clinical research process on our guide to clinical research for parents and children.

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Studies

INFUSE Bone Graft (recombinant human Bone Morphogenetic Protein-2/absorable collegen sponge) in the treatment of Tibial Psudarthrosis in Neurofibromatosis 1 (NF1)

ClinicalTrials.gov ID: NCT02718131

The current study proposes adding BMP-2 (INFUSE), an anabolic agent, at the surgical site of TPA repair in children with NF1, compared to a control group of patients treated surgically without BMP-2. The following Specific Aims will be addressed: 1) to determine if use of an osteogenic agent (BMP-2) at the time of surgical repair of TPA in NF1...

IMPAACT P1115 Very Early Intensive Treatment of HIV-Infected Infants to Achieve HIV Remission

IMPAACT P1115 will explore the effects of early intensive antiretroviral therapy (ART) on achieving HIV remission (HIV RNA below the limit of detection of the assay) among HIV-infected infants.

Slide Alone: Fracture Prevention in Toddlers and Youth (SAFETY)

This study will examine children diagnosed with a fracture that occurred while using a playground slide in order to understand the causes of these injuries.

Evaluating the Safety and Pharmacokinetics of VRC01, A Potent Anti-HIV Neutralizing Monoclonal Antibody, in HIV-1 Exposed Infants

ClinicalTrials.gov ID: NCT02256631

VRC01 and VRC01LS are anti-HIV neutralizing monoclonal antibodies that may help prevent mother-to-child transmission of HIV. This study will enroll HIV-infected mothers who are at increased risk of passing HIV on to their children. The purpose of this study is to assess the safety and PK of VRC01 and VRC01LS in HIV-exposed infants. This study will...

Pharmacokinetics of Anti-epileptic Drugs in Obese Children

ClinicalTrials.gov ID: NCT02993861

The study is a prospective, multi-center, open-label clinical trial. Study's purpose is to characterize the pharmacokinetics and safety of four oral anti-epileptics drugs (levetiracetam, valproic acid [divalproex sodium ER or immediate release formulation if inadequate enrollment}, topiramate, and oxcarbazepine) in a non-randomized sample of obese...