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Clinical Studies

Clinical research is very important because it is one of the best ways to improve patient care. Currently, hundreds of studies are taking place throughout Lurie Children's, including at the research institute, that involve many of our doctors, nurses, clinical research professionals, scientists and technicians.

Search below for a clinical study, or to see a more comprehensive listing of the clinical studies taking place at Lurie Children's, please use our link to the ClinicalTrials.gov website.

You can learn more about the clinical research process on our guide to clinical research for parents and children.

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Studies

Phase I/II Study of the Safety, Acceptability, Tolerability, and Pharmacokinetics of Oral and Long-Acting Injectable Cabotegravir and Long-Acting Injectable Rilpivirine in Virologically Suppressed HIV-Infected Children and Adolescents

ClinicalTrials.gov ID: NCT03497676

To confirm the dose and evaluate the safety, tolerability, acceptability, and pharmacokinetics (PK) of oral cabotegravir (CAB), long-acting injectable cabotegravir (CAB LA), and long-acting injectable rilpivirine (RPV LA) in virologically suppressed HIV‐1 infected children and adolescents aged 12 to <18 years.

Open-label Access to Dolutegravir for HIV-1 Infected Children and Adolescents Completing IMPAACT Studies P1093 and P2019

ClinicalTrials.gov ID: NCT03016533

To assess the pharmacokinetics (PK), safety, and tolerability of fixed dose combination abacavir (ABC)/ dolutegravir (DTG)/ lamivudine (3TC) in HIV-1-infected children.

Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum

ClinicalTrials.gov ID: NCT04518228

To describe the pharmacokinetic (PK) properties of antiretroviral (ARV) and anti-tuberculosis (TB) drugs administered during pregnancy and postpartum.

Efficacy of a Peri-Operative Surgical-Site, Multimodal Drug Injection in Pediatric Patients with Cerebral Palsy Undergoing Hip Surgery: A Randomized Controlled Trial

ClinicalTrials.gov ID: NCT04074265

The goal of this prospective study is to assess the efficacy of pre-operative surgical site drug injection in pediatric patients with cerebral palsy undergoing hip surgery. Patients will be randomly assigned to the 2 treatment groups: surgical-site injection with ropivacaine, ketorolac, and epinephrine, or surgical-site injection with normal...

Tiny Cargo, Big Deal! An ED-Based Study of Child Passenger Safety Behaviors

ClinicalTrials.gov ID: NCT04238247

Motor vehicle collisions remain the leading cause of unintentional injury deaths among children in the United States despite the availability of car seats and booster seats that are effective in preventing injuries. Some communities are disproportionately impacted by deaths in crashes because of suboptimal child passenger safety behaviors. This...