About Stanley Manne Children's Research Institute

Kawasaki cellsResearch at Ann & Robert H. Lurie Children’s Hospital of Chicago is conducted through Stanley Manne Children's Research Institute. The institute is focused on improving child health, transforming pediatric medicine and ensuring healthier futures through the relentless pursuit of knowledge. In partnership with Northwestern University Feinberg School of Medicine, our scientists work in labs, in clinics, at the patient bedside and in the community to unravel the root causes of pediatric and adolescent disease, to understand childhood injury and to find factors that precipitate health problems in childhood and over a lifetime. Our researchers work every day to develop new therapies and prevention strategies.

Image: Detection of antigen in Kawasaki disease ciliated bronchial epithelial cells by Kawasaki disease synthetic antibody (arrows, brown stain). Image courtesy of Anne Rowley, MD.

Our Name

In recognition of a transformative gift from Mr. Stanley Manne, a retired local business executive and Chairman of the Manne Family Foundation, the institute was named Stanley Manne Children’s Research Institute in May 2014.

The gift will provide funding to help sustain and further enhance medical research into the causes and cures of childhood disease at Lurie Children’s. When asked why he chose to make this gift to establish the Manne Research Institute, Mr. Manne said, “I have always wanted to give something back to individuals who wish to rise above their challenges. I chose Lurie Children’s for this gift because I have personally seen children grow healthy through successful treatment at the hospital. These children are now adults who are making a difference in society.” Mr. Manne was also impressed by the leadership at Lurie Children’s and their capability to deliver on the promise of the institution’s mission of patient care, research, education and advocacy.

Our History

Established in 1986 and guided by founding director Bernard L. Mirkin, PhD, MD, the research institute became one of the nation's leading free standing pediatric research entities attracting prominent and innovative scientists.

In 2007, under the leadership of Mary J.C. Hendrix, PhD, the research institute became a virtual center for all research conducted by Lurie Children's investigators – whether in the research facility, in the hospital, at the Feinberg School or throughout the community.

Thomas P. Shanley, MD, joined the faculty in 2015 as Chair of the Department of Pediatrics, Founders' Board Centennial Professor, and Professor of Pediatrics at the Feinberg School, and Chief Research Officer at the Manne Research Institute. As Chief Research Officer, Shanley has appointed several faculty members as Associate Chief Research Officers (ACROs) so that each will build programs based on the research strengths and aspirations of faculty conducting research at Lurie Children’s. These ACROs are:

  • Matthew M. Davis, MD, MAPP, Associate Chief Research Officer for Health Services and Policy Research
  • Susanna A. McColley, MD, Associate Chief Research Officer for Clinical Trials
  • Patrick C. Seed, MD, PhD, Associate Chief Research Officer for Basic Science Research

Our Future

The Manne Research Institute is embarking on a move to the Simpson Querrey Biomedical Research Center on Northwestern University's Chicago campus in 2019. We look forward to continuing a robust research enterprise to investigate and address the challenges of childhood diseases, including the clinical, genetic, developmental and public health aspects of child health. As part of our commitment to a healthier future for all children, we plan to expand our research programs to include areas such as:


  • Precision medicine
  • Fertility preservation
  • Perinatal origins of disease
  • Host-microbial interactions, inflammation and immunity
  • Neurosciences and neurodevelopmental aspects
  • Pain
  • Food allergy
  • Gender and sex development

We will continue to seek new opportunities to address childhood health issues based on the needs of the populations we serve.