Xiao-Di Tan team publishes a top story

The top story appearing in Intestinal Cell News is a publication by a team led by Xiao-Di Tan, MD, a researcher at Lurie Children's. The research group investigated the mechanisms by which the long non-coding RNA H19, imprinted maternally expressed transcript (H19) regulates regeneration of intestinal epithelium using cell cultures and mouse models of inflammation. This inflammation is key to the pathogenesis of disease. The researchers discovered that H19 responds to inflammation in intestinal epithelial cells and plays an important role in sustaining intestinal epithelial regeneration under inflammatory conditions. This finding, published in the journal Gastroenterology, may reveal new therapeutic avenues to intervene in cases of inflammation-associated gut mucosal pathology such as delayed mucosal healing and inflammatory bowel disease-associated colon cancers.