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Clinical Studies

Clinical research is very important because it is one of the best ways to improve patient care. Currently, hundreds of studies are taking place throughout Lurie Children's, including at the research institute, that involve many of our doctors, nurses, clinical research professionals, scientists and technicians.

Search below for a clinical study, or to see a more comprehensive listing of the clinical studies taking place at Lurie Children's, please use our link to the ClinicalTrials.gov website.

You can learn more about the clinical research process on our guide to clinical research for parents and children.

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Studies

Phase I/II Study of the Safety, Acceptability, Tolerability, and Pharmacokinetics of Oral and Long-Acting Injectable Cabotegravir and Long-Acting Injectable Rilpivirine in Virologically Suppressed HIV-Infected Children and Adolescents

ClinicalTrials.gov ID: NCT03497676

To confirm the dose and evaluate the safety, tolerability, acceptability, and pharmacokinetics (PK) of oral cabotegravir (CAB), long-acting injectable cabotegravir (CAB LA), and long-acting injectable rilpivirine (RPV LA) in virologically suppressed HIV‐1 infected children and adolescents aged 12 to <18 years.

Tiny Cargo, Big Deal! An ED-Based Study of Child Passenger Safety Behaviors

ClinicalTrials.gov ID: NCT04238247

Motor vehicle collisions remain the leading cause of unintentional injury deaths among children in the United States despite the availability of car seats and booster seats that are effective in preventing injuries. Some communities are disproportionately impacted by deaths in crashes because of suboptimal child passenger safety behaviors. This...

Open-label Access to Dolutegravir for HIV-1 Infected Children and Adolescents Completing IMPAACT Studies P1093 and P2019

ClinicalTrials.gov ID: NCT03016533

To assess the pharmacokinetics (PK), safety, and tolerability of fixed dose combination abacavir (ABC)/ dolutegravir (DTG)/ lamivudine (3TC) in HIV-1-infected children.

Improving Medication Adherence in Adolescents Who Had a Liver Transplant (iMALT)

ClinicalTrials.gov ID: NCT03691220

This is a prospective, multi-center, randomized controlled trial. The study will be conducted in 11 transplant centers in the United States and Canada. Estimated final sample size of 140. Pediatric adolescent and young adult (age at enrollment ≥12 and < 18) transplant recipients will be eligible for participation in the study. Eligible...

Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum

ClinicalTrials.gov ID: NCT04518228

To describe the pharmacokinetic (PK) properties of antiretroviral (ARV) and anti-tuberculosis (TB) drugs administered during pregnancy and postpartum.