Angela Waanders, MD, MPH

Angela Waanders, MD, MPH

Director, Precision Medicine Oncology; Program Director, Pediatric Neuro-Oncology Fellowship; Executive Board Chair, Children's Brain Tumor Tissue Consortium Associate Professor of Pediatrics (Hematology, Oncology, and Stem Cell Transplantation), Northwestern University Feinberg School of Medicine Max Lacewell Endowed Brain Tumor Research Scholar

Language: English

Appointments & Referrals

1.800.543.7362 (1.800.KIDS DOC)

Education & Training

Education: Tulane University School of Medicine, 2003

Postgraduate Training: Fellowship in pediatric hematology/oncology, Children's Hospital of Philadelphia, 2006-2009; Residency is pediatrics, Children's Hospital of Philadelphia, 2003-2006

Board Certifications: Pediatrics, Pediatric Hematology-Oncology

See Northwestern University Faculty Profile >

Research

Publications

(Sievert AJ is former name)

Sievert AJ, Jackson EM, Gai X, Hakonarson H, Judkins AR, Resnick AC, Sutton LN, Storm PB, Shaikh TH, Biegel JA. Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single –nucleotide polymoprhism-based genotype arrays results in a novel BRAF fusion gene. Brain Pathology 2009 Jul; 19 (3):449-58. Epub 2008 Oct 21. PMID: 19016743

Jackson EM, Sievert AJ, Gai X, Hakonarson H, Judkins AR, Tooke L, Perin JC, Xie H, Shaikh TH, Biegel JA. Genomic Analysis Using High-Density Single Nucleotide Polymorphism-Based Oligonucleotide Arrays and Multiplex Ligation-Dependent Probe Amplification Provides a Comprehensive Analysis of INI1/SMARCB1 in Malignant Rhabdoid Tumors. Clinical Cancer Research March 15, 2009; 15 (6):1923.1930. Epub 2009 Mar 10. PMID: 19276269

Dougherty MJ, Santi M, Brose MS, Ma C, Resnick AC, Sievert AJ, Storm PB, Biegel JA. Activating mutations in BRAF characterize a spectrum of low-grade gliomas. Neuro Oncology 2010 Jul; 12 (7): 621-30. Epub 2010 Feb 14. PMID: 20156809

Stephens, J, Sievert AJ, Judkins AR, Resnick AC, Storm PB, Rushing E, Santi M. Spinal cord ependymomas and myxopapillary ependymomas in the first two decades of life: a clinicopathological and immunohistochemical characterization of 19 cases. J of Neurosurg Pediatr. 2012 Jun; 9 (6):646-53. PMID: 22656257

Sievert AJ, Lang SS, Boucher KL, Madsen PJ, Slaunwhite E, Choudhari N, Kellet M, Storm PB, and Resnick AC. Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. PNAS 2013 April; 110 (15): 5957-5962. Epub 2013 Mar 26. PMID: 23533272

Karajannis MA, Legault G, Fisher MJ, Milla SS, Cohen KJ, Wisoff JH, Harter DH, Goldbery JD, Hochman T, Merkelson A, Bloom MC, Sievert AJ, Resnick AC, Dhall G, Jones DTW, Korshunov A, Pfister SM, Eberhart CG, Zagzag D, and Allen JC. Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas. Neuro Oncol. 2014 May 6. [Epub ahead of print]. PMID: 24803676

Goldberg EM, Titulaer M, de Blank PM, Sievert A, Ryan N. Anti-N-methyl-D aspartate receptor-mediated encephalitis in infants and toddlers: case report and review of literature. Pediatr Neurol 2014 Feb; 50(2): 181-4. Doi: 10.1016/j.pediatrneurol.2013.10.002. Epub 2013 Oct 14. PMID: 24315538

Jenssen BP, Lautz AJ, Orthmann-Murphy JL, Yum SW, Waanders AJ, Fox E. A 6-year old with Leg Cramps. Pediatrics. Oct 2015; 136 (4): 732-739; DOI: 10.1542/peds.2015-0332. Epub 2015 Sept 14. PMID: 26371189

Jones CL, Gearheart CM, Fosmire S, Delgado-Martin C, Evensen NA, Waanders AJ, Pais F, Wang J, Bhatia T, Bitterman DS, de Rijk SR, Bourgeois W, Dandekar S, Park E, Burleson TM, Madhusoodhan PP, Teachey DT, Raetz EA, Hermiston ML, Muschen M, Loh ML, Hunger SP, Zhang J, Garabedian MJ, Porter CC, Carroll WL. MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia. Blood. 2015 Nov 5; 126 (19): 2202-12. Doi:10.1182/blood-2015-04-639138. Epub 2015 Aug 31. PMID: 26324703

Shah AC, Minturn JE, Li Y, Belasco JB, Phillips PC, Kang TI, Cole KA, Waanders AJ, Pollack R, Didomenico C, Wildes C, Fisher MJ. Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma. Pediatr Blood Cancer. 2015 Jul 31. Doi: 10.1002/pbc.25697. [Epub ahead of print]. PMID: 26235452

Bandopadhayay P, Ramkissoon LA, Jain P, Bergthold G, Wala J, Zeid R, Schumacher SE, Urbanski L, O'Rourke R, Gibson WJ, Pelton K, Ramkissoon SH, Han HJ, Zhu Y, Choudhari N, Silva A, Boucher K, Henn RE, Kang YJ, Knoff D, Paolella BR, Gladden-Young A, Varlet P, Pages M, Horowitz PM, Federation A, Malkin H, Tracy AA, Seepo S, Ducar M, Van Hummelen P, Santi M, Buccoliero AM, Scagnet M, Bowers DC, Giannini C, Puget S, Hawkins C, Tabori U, Klekner A, Bognar L, Burger PC, Eberhart C, Rodriguez FJ, Hill DA, Mueller S, Haas-Kogan DA, Phillips JJ, Santagata S, Stiles CD, Bradner JE, Jabado N, Goren A, Grill J, Ligon AH, Goumnerova L, Waanders AJ, Storm PB, Kieran MW, Ligon KL, Beroukhim R, Resnick AC. MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. Nat Genet. 2016 March; 48 (3):273-82. Doi: 10.1038/ng.3500. Epub 2016 Feb 1. PMID: 26829751

Roth JJ, Fierst TM, Waanders AJ, Li Yimei, Biegel JA, Santi M. Whole chromosome 7 gain predicts higher risk of recurrence in pediatric pilocytic astrocytomas independently from KIAA1549-BRAF fusion status. J Neuropathol Exp Neurol. 2016 Mar 4. Pil: nlw001. [Epub ahead of print]. PMID 26945035

Olow A, Mueller S, Yang X, Hashizume R, Meyerowitz J, Weiss W, Resnick AJ, Waanders AJ, Stalpers LJ, Berger MS, Gupta N, James CD, Petritsch CK, Haas-Kogan DA. BRAF status in personalizing treatment approaches for pediatric gliomas. Clin Cancer Res. 2016 Nov1; 22 (21):5312-5321. Epub 2016 May 23. PMID: 27217440

Jain P, Fierst TM, Han HJ, Smith TE, Vakil A, Storm PB, Resnick AC, Waanders AJ.
CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles. Oncogene. 2017 Aug 14. [Epub ahead of print]. PMID: 28806393

Mackay A, Burford A, Carvalho D, Izquierdo E, Salom JF, Taylor K, Bjerke L, Clarke M, Vinci M, Nandhabalan M, Temelso S, Popov S, Molinari V, Raman P, Waanders AJ, Han HJ, Gupta S, Marshall L, Zacharoulis S, Vaidya S, Mandeville HC, Bridges LR, Martin AJ, Al-Sarraj S, Chandler C, Ng HK, Li X, Mu K, Travelsi S, H’mida-Ben Brahim D, Kisljakov AN, Konovalov DM, Moore AS, Carcaboso AM, Sunoi M, de Torres C, Cruz O, Mora J, Shats LI, Stavale JN, Bidinotto LT, Reis RM, Entz-Werle N, Farrell M, Cryan J, Crimmins D, Caird J, Pears J, Monje M, Debily MA, Castel D, Grill J, Hawkins C, Nikbakht H, Jabado N, Baker SJ, Pfister SM, Jones DTW, Fouladi M, van Bueren AO, Baudis M, Resnick AC, and Jones C. Integrated molecular meta-analysis of 1000 paediatric high-grade and diffuse intrinsic pontine glioma. Cancer Cell. 2017 Oct 9; 32 (4):520-537.e5.doi: 10.1016/j.ccell.2017.08.017. Epub 2017 Sep 28. PMID: 28966033

Jones DTW, Kieran MW, Bouffet E, Alexandrescu S, Bandopadhayay P, Bornhorst M, Ellison D, Fangusaro J, Fisher MJ, Foreman N, Fouladi M, Hargrave D, Hawkins C, Jabado N, Massimino M, Mueller S, Perilongo G, Schouten van Meeteren AYN, Tabori U, Warren K, Waanders AJ, Walker D, Weiss W, Witt O, Wright K, Zhu Y, Bowers DC, Pfister SM, Packer RJ. Pediatric Low-Grade Gliomas: Next Biologically Driven Steps. Neuro-Oncol. 2018 Jan 22; 20 (2): 160-173. PMID: 29016845

Jain P, Silva A, Han HJ, Lang SS, Zhu Y, Boucher K, Smith TE, Vakil A, Diviney P, Choudhari N, Raman P, Busch CM, Delaney T, Yang X, Olow AK, Mueller S, Haas-Kogan D, Fox E, Storm PB, Resnick AC, Waanders AJ. Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways. Oncotarget. 2017 Sep 15; 8 (49): 84697-84713. PMID: 29156677

Gröbner SN, Worst BC, Weischenfeldt J, Buchhalter I, Kleinheinz K, Rudneva VA, Johann PD, Balasubramanian GP, Segura-Wang M, Brabetz S, Bender S, Hutter B, Sturm D, Pfaff E, Hübschmann D, Zipprich G, Heinold M, Eils J, Lawerenz C, Erkek S, Lambo S, Waszak S, Blattmann C, Borkhardt A, Kuhlen M, Eggert A, Fulda S, Gessler M, Wegert J, Kappler R, Baumhoer D, Burdach S, Kirschner-Schwabe R, Kontny U, Kulozik AE, Lohmann D, Hettmer S, Eckert C, Bielack S, Nathrath M, Niemeyer C, Richter GH, Schulte J, Siebert R, Westermann F, Molenaar JJ, Vassal G, Witt H; ICGC PedBrain-Seq Project; ICGC MMML-Seq Project, Burkhardt B, Kratz CP, Witt O, van Tilburg CM, Kramm CM, Fleischhack G, Dirksen U, Rutkowski S, Frühwald M, von Hoff K, Wolf S, Klingebiel T, Koscielniak E, Landgraf P, Koster J, Resnick AC, Zhang J, Liu Y, Zhou X, Waanders AJ, Zwijnenburg DA, Raman P, Brors B, Weber UD, Northcott PA, Pajtler KW, Kool M, Piro RM, Korbel JO, Schlesner M, Eils R, Jones DTW, Lichter P, Chavez L, Zapatka M, Pfister SM. The Landscape of genomic alterations across childhood cancer. Nature.2018 Mar 15; 555 (7696):321-327. Epub 2018 Feb 28. PMID: 29489754

Mackay A, Burford A, Molinari V, Jones DTW, Izquierdo E, Brouwer-Visser J, Giangaspero F, Haberler C, Pietsch T, Jacques TS, Figarella-Branger D, Rodriguez D, Morgan PS, Raman P, Waanders AJ, Resnick AC, Massimino M, Garrè ML, Smith H, Capper D, Pfister SM, Würdinger T, Tam R, Garcia J, Thakur MD, Vassal G, Grill J, Jaspan T, Varlet P, Jones C. Molecular, Pathological, Radiological, and Immune Profiling of Non-Brainstem High Grade Glioma from the HERBY Phase II Randomized Trial. Cancer Cell. 2018 May 14; 33 (5): 829-842. PMID: 29763623.

Jain P, Surrey LF, Straka J, Luo M, Lin F, Harding B, Resnick AC, Storm PB, Buccoliero AM, Santi M, Li MM, Waanders AJ. Novel FGFR2-INA fusion identified in two low-grade mixed neuronal-glial tumors drives oncogenesis via MAPK and PI3K/mTOR pathway activation. Acta Neuropathol. 2018 May 16. [Epub ahead of print]. PMID: 29767381

Foster JB, Choudhari N, Perezzelli J, Storm J, Hoffmann TJ, Jain P, Storm PB, Pardi N, Weissman D, Waanders AJ, Grupp SA, Kariko K, Resnick AC, Barrett DM. Purification of mRNA encoding chimeric antigen receptor is critical for generation of robust T cell response. Hum Gene Ther. 2019 Feb; 30 (2): 168-178. Doi: 10.1089/hum.2018.145.Epub 2018 Oct 2. PMID: 30024272

Leibowitz M, Wolfe H, Flynn A, Waanders A, Burlingame C, Aumaier B, Friedman D, Lambert MP. Transfusion, 2018 Dec;58(12):2836-2840. doi: 10.1111/trf.14924. Epub 2018 Sep 27. PMID: 30264395

Mueller S, Jain P, Liang WS, Kilburn L, Kline C, Gupta N, Panditharatna E, Magge SN, Zhang B, Zhu Y, Crawford JR, Banerjee A, Nazemi K, Packer RJ, Petritsch CK, Truffaux N, Roos A, Nasser S, Phillips JJ, Solomon D, Molinaro A, Waanders AJ, Byron SA, Berens ME, Kuhn J, Nazarian J, Prados M, Resnick AC. A pilot precision medicine trial for children with diffuse intrinsic pontine glioma- PNOC003: A report from the Pacific Pediatric Neuro-Oncology Consortium. Int J Cancer. 2019 Mar 12. Doi: 10.1002/ijc.32258. [Epub ahead of print]. PMID: 30861105

Frisoli F, Karaenka M, Cole KA, Waanders AJ, Storm PB, Lang SS. Endoscopic third ventriculostomy prior to resection of posterior fossa tumors in children. Childs Nerv Syst. 2019 Mar 20. Doi: 10.1007/s00381-019-04125-z. [Epub ahead of print]. PMID: 30895380

Surrey LF, MacFarland SP, Chang F, Cao K, Rathi KS, Akgumus GT, Gallo D, Lin F, Gleason A, Raman P, Aplenc R, Bagatell R, Minturn J, Mosse Y, Santi M, Tasian SK, Waanders AJ, Sarmady M, Maris JM, Hunger SP, Li MM. Clinical utility of custom-designed NGS panel testing in pediatric tumors. Genome Med. 2019 May 28; 11(1):32. Doi: 10.1186/213073-019-0644-8. PMID: 31133068

Shenoy A, Surrey L, Jain P, Foster J, Straka J, Resnick A, Waanders A, Luo M, Li M, Kazahaya K, Bagatell R, Wojcik J, Pogoriler J. Sclerosing Epithelioid Fibraosarcoma of the Bone with Rare EWSR1-CREB3L3 Translocation Driving Upregulation of the PI3K/mTOR Signaling Pathway. Pediatr Dev Pathol. Jul 23: 1093526619864230. Doi: 10. 1177/1093526619864230. [Epub ahead of print] PMID: 31335288.

Lang S.S., J. Ploof, N. Atkin, K. Tran-Du, B. Kanuga, P.B. Storm, G. Heuer, I. Yuan, N. Abend, M. Kirschen, A. Topjian, Y. Li, A. Waanders, J. Zorc, J. Huh. Decadron, Diamox, and Zantac (DDZ): A Novel Combination for Ventricular Shunt Failure in Pediatric Neurosurgical Patients. Pediatric Emergency Care. 2019 Aug. [epub ahead of print]

Chi AS, Tapaore RS, Hall MD, Shonka N, Gardner S, Umermura Y, Sumrali A, Khatib Z, Mueller S, Kline C, Zaky W, Khatau S, Weathers SP, Odia Y, Niazi TN, Daghistani D, Cherrick I, Korones D, Karajannis MA, Kong XT, Minturn J, Waanders A, Arillaga-Romany I, Batchelor T, Wen PY, Merdinger K, Schalop L, Stogniew M, Allen JE, Oster W, Mehta MP. Pediatric and adult H3.K27M-mutant diffuse midline glioma treated with selective DRD2 antagonist ONC201. J Neurooncol. 2019 Aug 27. Doi: 10.1007/s11060-109-03271-3. [Epub ahead of print] PMID: 31456142

Chang F, Lin F, Cao K, Surrey LF, Aplenc R, Bagatell R, Resnick AC, Santi M, Storm PB, Tasian SK, Waanders AJ, Hunger SP, Li MM. Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers. J Mol Diagn. 2019 Sep; 21 (5): 873-883. Doi: 10. 1016/j.moldx.2019.05.006.Epub 2019 Jun 27. PMID: 31255796.

Matesanz S, Kotch C, Perrone C, Waanders AJ, Hill B, Narula S. Expanding the MOG phenotype: Brainstem encephalitis with punctate and curvilinear enhancement. Neurol Neuroimmunol Neuroinflamm. 2019 Sept 13; 6(6). PMID: 3159713

Vogel J, Grewal A, O'Reilly S, Lustig R, Kurtz G, Minturn JE, Shah AC, Waanders AJ, Belasco JB, Cole KA, Fisher MJ, Phillips PC, Balamuth NJ, Storm PB, Hill-Kayser CE. Risk of brainstem necrosis in pediatric patients with central nervous system malignancies after pencil beam scanning proton therapy. Acta Oncol. 2019 Sep 12: 1-5. [Epub ahead of print]. PMID: 31512931

Lang SS, Khanna O, Atkin NJ, Palma JE, Yuan I, Storm PB, Heuer GG, Kennedy B, Waanders AJ, Li Y, Huh JW, Journal of neurosurgery. Perioperative near-infrared spectroscopy cerebral oxygen saturation in symptomatic pediatric hydrocephalus at risk for intracranial hypertension. Pediatrics. 2019 Nov 29; 1-7 [Epubahead of print]. PMID 31783356.

Connors M, Paden W, Storm PB, Waanders AJ, Lang SS. Low-grade astrocytoma in the setting of a developmental venous anomaly. Child’s Nervous System. 2019
Nov 27 [Epub ahead of pring]. PMID 31776715

Surrey LF, Jain P, Zhang B, Straka J, Zhao X, Harding BN, Resnick AC, Storm PB, Buccoliero AM, Genitori L, Li MM, Waanders AJ, Santi M. Genomic analysis of dysembroplastic neuroepithelial tumor spectrum reveals a diversity of molecular alterations dysregulating the MAPK and PI3K/mTOR pathways. Journal of neuropathology and experimental neurology. 2019 Dec 01; 78 (12): 1100-1111. PMID 31617914

Ijaz H, Koptyra M, Gaonkar KS, Rokita JL, Baubet VP, Tauhid L, Zhu Y, Brown M, Lopez G, Zhang B, Diskin SJ, Vaksman Z, Mason JL, Appert E, Lilly J, Lulla R, De Raedt T, Heath AP, Felmeister A, Raman P, Nazarian J, Santi MR, Storm PB, Resnick A, Waanders AJ, Cole KA. Pediatric high-grade glioma resources from the Children’s Brain Tumor Tissue Consortium. Neuro-oncology. 2020 Jan 11; 22 (1): 163-165.

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