Simone T. Sredni, MD, PhD

Research Associate Professor of Neurological Surgery, Northwestern University Feinberg School of Medicine

Director, Initiative for the Study and Translational ATRT Research (iSTAR AT/RT), Stanley Manne Children's Research Institute

Language: English

Education & Training

Education: Santa Casa Medical School, São Paulo, Brazil, 1990,

Postgraduate Training: University of São Paulo, Brazil, Pathology, 1999

Research

Research Interests: Cancer biology; cancer genetics; cancer: pediatric non-sarcoma solid tumors; pediatric embryonal tumors; rhabdoid tumors; AT/RT; cancer: brain and nervous system; cancer: genomics; pathology

Publications

Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer
Int J Mol Sci20 (9):
Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma
Oncotarget8 (67): 111190-111212
The polo-like kinase 4 gene (PLK4) is overexpressed in pediatric medulloblastoma
Childs Nerv Syst33 (7): 1031
A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain
Pediatr Blood Cancer64 (11):
Stabilization of HIF-1alpha and HIF-2alpha, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model
PLoS One12 (3): e0173106

See All

Simone T. Sredni, MD, PhD

Simone T. Sredni, MD, PhD

Research Associate Professor of Neurological Surgery, Northwestern University Feinberg School of Medicine

Director, Initiative for the Study and Translational ATRT Research (iSTAR AT/RT), Stanley Manne Children's Research Institute

Education & Training

Research

Publications

Related News & Stories

Promising Target for Treating Brain Tumors in Children

New Potential Treatment for Aggressive Brain Cancer in Children