Simone T. Sredni, MD, PhD

Research Associate Professor of Neurological Surgery, Northwestern University Feinberg School of Medicine

Director, Initiative for the Study and Translational ATRT Research (iSTAR AT/RT), Stanley Manne Children's Research Institute

Language: English

Education & Training

Education: Santa Casa Medical School, São Paulo, Brazil, 1990,

Postgraduate Training: University of São Paulo, Brazil, Pathology, 1999

Research

Research Interests: Cancer biology; cancer genetics; cancer: pediatric non-sarcoma solid tumors; pediatric embryonal tumors; rhabdoid tumors; AT/RT; cancer: brain and nervous system; cancer: genomics; pathology

Publications

Most recent publications

Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma Oncotarget8 (67): 111190-111212
The polo-like kinase 4 gene (PLK4) is overexpressed in pediatric medulloblastoma Childs Nerv Syst33 (7): 1031
A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain Pediatr Blood Cancer64 (11):
Stabilization of HIF-1alpha and HIF-2alpha, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model PLoS One12 (3): e0173106
Overexpression of TEAD4 in atypical teratoid/rhabdoid tumor: New insight to the pathophysiology of an aggressive brain tumor Pediatr Blood Cancer64 (7):
Spontaneous involution of pediatric low-grade gliomas: high expression of cannabinoid receptor 1 (CNR1) at the time of diagnosis may indicate involvement of the endocannabinoid system Childs Nerv Syst32 (11): 2061-2067
Extensive miRNA expression analysis in craniopharyngiomas Childs Nerv Syst32 (9): 1617-24
MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis J Rheumatol43 (1): 161-8
Atypical teratoid rhabdoid tumors of the posterior fossa in children Childs Nerv Syst31 (10): 1717-28
A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells PLoS One10 (3): e0121707

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Simone T. Sredni, MD, PhD

Simone T. Sredni, MD, PhD

Research Associate Professor of Neurological Surgery, Northwestern University Feinberg School of Medicine

Director, Initiative for the Study and Translational ATRT Research (iSTAR AT/RT), Stanley Manne Children's Research Institute

Education & Training

Research

Publications

Related News & Stories

Promising Target for Treating Brain Tumors in Children

New Potential Treatment for Aggressive Brain Cancer in Children

Double Your Impactfor Kids likeGeorge and Summer

Simone T. Sredni, MD, PhD

Simone T. Sredni, MD, PhD

Research Associate Professor of Neurological Surgery, Northwestern University Feinberg School of Medicine

Director, Initiative for the Study and Translational ATRT Research (iSTAR AT/RT), Stanley Manne Children's Research Institute

Education & Training

Research

Publications

Related News & Stories

Promising Target for Treating Brain Tumors in Children

New Potential Treatment for Aggressive Brain Cancer in Children

Double Your Impact
for Kids like
George and Summer