Simone T. Sredni, MD, PhD

Research Associate Professor of Neurological Surgery, Northwestern University Feinberg School of Medicine

Director, Initiative for the Study and Translational ATRT Research (iSTAR AT/RT), Stanley Manne Children's Research Institute

Education & Training

Education: Santa Casa Medical School, São Paulo, Brazil, 1990,

Postgraduate Training: University of São Paulo, Brazil, Pathology, 1999

Research

Research Interests: Cancer biology; cancer genetics; cancer: pediatric non-sarcoma solid tumors; pediatric embryonal tumors; rhabdoid tumors; AT/RT; cancer: brain and nervous system; cancer: genomics; pathology

Publications

Most recent publications

Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma Oncotarget 8 (67): 111190-111212
The polo-like kinase 4 gene (PLK4) is overexpressed in pediatric medulloblastoma Childs Nerv Syst 33 (7): 1031
A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain Pediatr Blood Cancer 64 (11):
Stabilization of HIF-1alpha and HIF-2alpha, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model PLoS One 12 (3): e0173106
Overexpression of TEAD4 in atypical teratoid/rhabdoid tumor: New insight to the pathophysiology of an aggressive brain tumor Pediatr Blood Cancer 64 (7):
Spontaneous involution of pediatric low-grade gliomas: high expression of cannabinoid receptor 1 (CNR1) at the time of diagnosis may indicate involvement of the endocannabinoid system Childs Nerv Syst 32 (11): 2061-2067
Extensive miRNA expression analysis in craniopharyngiomas Childs Nerv Syst 32 (9): 1617-24
MicroRNA-10a Regulation of Proinflammatory Mediators: An Important Component of Untreated Juvenile Dermatomyositis J Rheumatol 43 (1): 161-8
Atypical teratoid rhabdoid tumors of the posterior fossa in children Childs Nerv Syst 31 (10): 1717-28
A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells PLoS One 10 (3): e0121707

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News

2 Results

Promising Target for Treating Brain Tumors in Children

New Potential Treatment for Aggressive Brain Cancer in Children

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