Simone T. Sredni, MD, PhD

Research Associate Professor of Neurological Surgery, Northwestern University Feinberg School of Medicine Director, Initiative for the Study and Translational ATRT Research (iSTAR AT/RT), Stanley Manne Children's Research Institute

Language: English

Education & Training

Education: Santa Casa Medical School, São Paulo, Brazil, 1990

Postgraduate Training: University of São Paulo, Brazil, Pathology, 1999

Research

Research Interests: Cancer biology; cancer genetics; cancer: pediatric non-sarcoma solid tumors; pediatric embryonal tumors; rhabdoid tumors; AT/RT; cancer: brain and nervous system; cancer: genomics; pathology

Publications

Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer
Int J Mol Sci20 (9):
Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma
Oncotarget8 (67): 111190-111212
The polo-like kinase 4 gene (PLK4) is overexpressed in pediatric medulloblastoma
Childs Nerv Syst33 (7): 1031
A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain
Pediatr Blood Cancer64 (11):
Stabilization of HIF-1alpha and HIF-2alpha, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model
PLoS One12 (3): e0173106

See All