Isabelle De Plaen, MD

Attending Physician, Neonatology

Associate Professor of Pediatrics-Neonatology, Northwestern University Feinberg School of Medicine

Appointments & Referrals

1.800.543.7362 (1.800.KIDS DOC)

About Me

Clinical Interests: Mechanisms of gut injury-necrotizing enterocolitis

Specialties, Programs & Conditions

Specialties:

Neonatal Intensive Care Unit (NICU) >

Education & Training

Education: Catholic University of Louvain School of Medicine, Brussels, Belgium, 1989

Postgraduate Training: Northwestern University Medical School, 1998; Catholic University of Louvain School of Medicine, Brussels, Belgium, 1995; California Pacific Medical Center, Children's Hospital, San Francisco, 1994

Board Certifications: Neonatal-Perinatal Medicine, General Pediatrics

Research

Research Interests: Cytokines; Digestive System (including gallbladder and liver); Immunology; Necrotizing Enterocolitis; Neonatal Necrotizing Entercolitis; Pediatrics

Publications

Most recent publications

In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration Gastroenterology 155 (1): 144-155
Dimethyloxalylglycine preserves the intestinal microvasculature and protects against intestinal injury in a neonatal mouse NEC model: role of VEGF signaling Pediatr Res
Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease J Immunol 199 (5): 1886-1897
A Role for cAMP and Protein Kinase A in Experimental Necrotizing Enterocolitis Am J Pathol 187 (2): 401-417
Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8 gene expression and restores enterocyte migration in lipopolysaccharide-induced septic mice Sci Rep 6 31687
Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection Am J Pathol 186 (7): 1837-46
Lack of VEGFR2 signaling causes maldevelopment of the intestinal microvasculature and facilitates necrotizing enterocolitis in neonatal mice Am J Physiol Gastrointest Liver Physiol 310 (9): G716-25
Molecular Mechanisms Underlying the Regulation of the MFG-E8 Gene Promoter Activity in Physiological and Inflammatory Conditions J Cell Biochem 116 (9): 1867-79
Intestinal vascular endothelial growth factor is decreased in necrotizing enterocolitis Neonatology 107 (3): 191-8
Inflammatory signaling in NEC: Role of NF-kappaB, cytokines and other inflammatory mediators Pathophysiology 21 (1): 55-65