Isabelle De Plaen, MD

Attending Physician, Neonatology

Associate Professor of Pediatrics-Neonatology, Northwestern University Feinberg School of Medicine

Language: English

Appointments & Referrals

1.800.543.7362 (1.800.KIDS DOC)

About Me

Clinical Interests: Mechanisms of gut injury-necrotizing enterocolitis

Specialties, Programs & Conditions

Specialties:

Neonatology

Education & Training

Education: Catholic University of Louvain School of Medicine, Brussels, Belgium, 1989

Postgraduate Training: Northwestern University Medical School, 1998; Catholic University of Louvain School of Medicine, Brussels, Belgium, 1995; California Pacific Medical Center, Children's Hospital, San Francisco, 1994

Board Certifications: Neonatal-Perinatal Medicine, General Pediatrics

Research

Research Interests: Cytokines; Digestive System (including gallbladder and liver); Immunology; Necrotizing Enterocolitis; Neonatal Necrotizing Entercolitis; Pediatrics

Publications

Most recent publications

Blocking NF-kappaB Activation in Ly6c(+) Monocytes Attenuates Necrotizing Enterocolitis Am J Pathol189 (3): 604-618
Intestinal microcirculation and necrotizing enterocolitis: The vascular endothelial growth factor system Semin Fetal Neonatal Med23 (6): 411-415
In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration Gastroenterology155 (1): 144-155
Dimethyloxalylglycine preserves the intestinal microvasculature and protects against intestinal injury in a neonatal mouse NEC model: role of VEGF signaling Pediatr Res
Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease J Immunol199 (5): 1886-1897
A Role for cAMP and Protein Kinase A in Experimental Necrotizing Enterocolitis Am J Pathol187 (2): 401-417
Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8 gene expression and restores enterocyte migration in lipopolysaccharide-induced septic mice Sci Rep631687
Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection Am J Pathol186 (7): 1837-46
Lack of VEGFR2 signaling causes maldevelopment of the intestinal microvasculature and facilitates necrotizing enterocolitis in neonatal mice Am J Physiol Gastrointest Liver Physiol310 (9): G716-25
Molecular Mechanisms Underlying the Regulation of the MFG-E8 Gene Promoter Activity in Physiological and Inflammatory Conditions J Cell Biochem116 (9): 1867-79

See All

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News

2 Results

Recently Published Research - Winter 2019

Study Offers Promise for Preventing Necrotizing Enterocolitis in Preemies

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