Isabelle De Plaen, MD

Attending Physician, Neonatology

Associate Professor of Pediatrics-Neonatology, Northwestern University Feinberg School of Medicine

Appointments & Referrals

1.800.543.7362 (1.800.KIDS DOC)

About Me

Clinical Interests: Mechanisms of gut injury-necrotizing enterocolitis

Specialties, Programs & Conditions

Specialties:

Neonatal Intensive Care Unit (NICU) >

Education & Training

Education: Catholic University of Louvain School of Medicine, Brussels, Belgium, 1989

Postgraduate Training: Northwestern University Medical School, 1998; Catholic University of Louvain School of Medicine, Brussels, Belgium, 1995; California Pacific Medical Center, Children's Hospital, San Francisco, 1994

Board Certifications: Neonatal-Perinatal Medicine, General Pediatrics

Research

Research Interests: Cytokines; Digestive System (including gallbladder and liver); Immunology; Necrotizing Enterocolitis; Neonatal Necrotizing Entercolitis; Pediatrics

Publications

Most recent publications

In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration Gastroenterology
Dimethyloxalylglycine preserves the intestinal microvasculature and protects against intestinal injury in a neonatal mouse NEC model: role of VEGF signaling Pediatr Res
Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease J Immunol 199 (5): 1886-1897
A Role for cAMP and Protein Kinase A in Experimental Necrotizing Enterocolitis Am J Pathol 187 (2): 401-417
Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8 gene expression and restores enterocyte migration in lipopolysaccharide-induced septic mice Sci Rep 6 31687
Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection Am J Pathol 186 (7): 1837-46
Lack of VEGFR2 signaling causes maldevelopment of the intestinal microvasculature and facilitates necrotizing enterocolitis in neonatal mice Am J Physiol Gastrointest Liver Physiol 310 (9): G716-25
Molecular Mechanisms Underlying the Regulation of the MFG-E8 Gene Promoter Activity in Physiological and Inflammatory Conditions J Cell Biochem 116 (9): 1867-79
Intestinal vascular endothelial growth factor is decreased in necrotizing enterocolitis Neonatology 107 (3): 191-8
Inflammatory signaling in NEC: Role of NF-kappaB, cytokines and other inflammatory mediators Pathophysiology 21 (1): 55-65