Tan Laboratory

The Tan laboratory investigates the pathogenesis of intestinal and liver inflammatory disorders such as inflammatory bowel disease, sepsis and severe inflammation-induced leaky gut, and fatty liver associated inflammation and tissue injury. Our goal is to advance our understanding of how inflammatory disorders occur in the gut and liver system. Clinical studies have shown that millions of children in our country suffer from GI (gastrointestinal) and liver inflammatory diseases. These disorders are often chronic and have huge impacts to patients’ lives not only in their childhoods but also extending to adulthood. Treatment of these diseases remains challenging to physicians. Thus, it is critical to fill this gap through basic and translational research. New knowledge and discovery from biomedical research can ultimately lead to novel therapies. 

Current Research Projects

Currently, investigators in the Tan laboratory are focused on understanding molecular and pathophysiological mechanisms that predispose to impairment of cell and immune homeostasis in the gut and liver, which in turn contribute to development of inflammatory diseases such as inflammatory bowel disease, sepsis, fatty liver associated hepatitis and liver fibrosis, and multiple organ failure. Our research is supported mainly by federal funding.

The Tan laboratory has several broad hypothesis-driven research projects that are aimed at addressing aspects related to inflammatory tissue injury and repair in the gut and liver systems:

  • Understanding the role of intestinal epithelial barrier in health and disease
  • Elucidating the pathophysiology and molecular mechanisms related to intestinal epithelial cell injury and repair
  • Examining the pathogenesis of fatty liver and obesity associated liver inflammation and progression to fibrosis and cirrhosis

Our work will ultimately lead to development of novel strategies for management and treatment of intestinal injury in critically ill patients. It will result in identification of new targets for blocking progression of fatty liver-associated liver inflammation and fibrosis.

​Publications

List of publications indexed in PubMed​ by the Tan Laboratory​​

Laboratory Members

  • Xiao Wang, MD, PhD, Assistant Research Professor
  • Hua Geng, PhD, Postdoctoral Associate
  • Hengfu (Henry) Bu, PhD, DVM, Assistant Research Professor 

Contact Information

Center for Intestinal and Liver Inflammation Research
Stanley Manne Children's Research Institute
Phone: 773.755.6360
Fax: 773.755.6581

Administrative Office
Marianne E Reed
E-mail: mereed@luriechildrens.org​
Phone: 773.755.6328
Fax: 773.755.6581