Klüppel Laboratory

 

My laboratory is interested in the functional roles of chondroitin sulfates and chondroitin sulfotransferase genes in mammalian development, disease and cellular signaling pathways. Specifically, we have been investigating the roles of the sulfotransferase C4ST-1/CHST11 and its chondroitin sulfate product CS-E in the contexts of breast cancer progression, the pediatric disease Costello syndrome, cardiovascular disease, developmental processes including ES cell differentiation and cell lineage determination, and in the control of Wnt/beta-catenin and HRAS signaling. Our long-term goal is the development of carbohydrate-based pharmacological interventions for the treatment of human diseases, including cancer and cardiovascular disease.

Current Research Projects

  • The Roles of CHST11 in Costello Syndrome and Other RASopathies
  • CHST11 and CS-E in the Control of Wnt/beta-catenin Signaling Thresholds
  • Chondroitin Sulfate Biosynthesis Machinery in Stem Cell Differentiation

​Publications

List of publications indexed in PubMed​ by ​the Klüppel Laboratory

Contact Information

E-mail: m-kluppel@northwestern.edu