Research Innovation


Who We Are

The research arm of Lurie Children’s, Stanley Manne Children's Research Institute helps us provide cutting-edge treatments and discover more effective ways to prevent and diagnose conditions that affect children’s health.

Our physicians and scientists are also faculty at Northwestern University Feinberg School of Medicine, our academic partner. Working closely together, our hospital, research institute and medical school train the next generation of pediatric specialists while advancing children's healthcare. 

Learn more about Stanley Manne and his gift.​​​

Read Our Research Blog

The research institute blog, From the Bench, is written by Philip M. Iannaccone, MD, PhD. Dr. Iannaccone's musings range from Mendelian inheritance to exactly how DNA controls human development. Stop by each week to see Dr. Iannaccone's take on research news, myths and surprises.  


Revised guidelines on the diagnosis of cystic fibrosis

Cystic fibrosis (CF) affects approximately 1 in 4,000 newborns in the U.S. each year. All U.S. states perform newborn screening to diagnose and start treatment early, but the results may prove inconclusive. To improve diagnosis and achieve standardization in definitions, an international committee of experts (including Susanna McColley, MD) developed clear and actionable consensus guidelines on diagnosis, which were published​ in February 2017. Read more.

Children born with heart defects at increased risk for epilepsy

Children with congenital heart disease have a higher risk of the seizure disorder epilepsy through adulthood, according to a Northwestern Medicine study published in the journal Circulation. Bradley Marino, MD, MPP, MSCE, Professor of Pediatrics in the Division of Cardiology, and an attending physician in Cardiology at Lurie Children's, was a co-author of the paper.​ Read more.​

Lab identifies a gene that plays a role in AT/RT aggressiveness

The laboratory of Simone Treiger Sredni, MD, PhD, has identified a gene called TEAD4 that had not been previously implicated in atypical teratoid/rhabdoid tumor (AT/RT), a highly aggressive brain tumor that occurs mainly in early childhood. This discovery helps to clarify the aggressiveness of this tumor.​ The research is published in Pediatric Blood and Cancer.​​ Research scholar Mario Suzuki, MD (pictured at left), was first author on the publication. Sredni is a member of the Cancer Biology and Epigenomics Program of the Manne Research Institute and Research Associate Professor of Neurological Surgery​ at the Feinberg School. Read more.​