Who We Are

The research arm of Lurie Children’s, Stanley Manne Children's Research Institute helps us provide cutting-edge treatments and discover more effective ways to prevent and diagnose conditions that affect children’s health.

Our physicians and scientists are also faculty at Northwestern University Feinberg School of Medicine, our academic partner. Working closely together, our hospital, research institute and medical school train the next generation of pediatric specialists while advancing children's healthcare. 

Learn more about Stanley Manne and his gift.​​​

Read Our Research Blog

The research institute blog, From the Bench, is written by Philip M. Iannaccone, MD, PhD. Dr. Iannaccone's musings range from Mendelian inheritance to exactly how DNA controls human development. Stop by each week to see Dr. Iannaccone's take on research news, myths and surprises.  


Promising strategy for treating rare forms of leukemia discovered

November 16, 2015 - by Nora Dunne

John Crispino, PhD and colleagues have identified a drug that stops the reproduction of cancer cells in models of primary myelofibrosis, a rare and incurable form of chronic leukemia. The study, published in Nature Medicine, shows that Alisertib has an anti-tumor effect in samples. Read the full story​.

Prevention and repair of spina bifida before birth

 The Pediatric Neurosurgery Laboratory seeks to uncover mechanisms behind normal fetal development, and what causes babies to be born with spina bifida. C. Shekhar Mayanil, PhD​​, who oversees the research program of the laboratory, says, “We know that the protein folate receptor-alpha (FRα) is critical for embryonic development.” The lab recently discovered a novel role for FRα. Read more.​

Genes that compete to regulate cell proliferation and cancer

The Hedgehog (Hh) signal transduction pathway is crucial for normal cellular growth and differentiation in animals. GLI family transcription factors GLI1, GLI2 and GLI3 mediate Hh signaling during development, playing critical roles. GLI1 and GLI2 have been associated with a wide variety of cancers. In a publication that appears in DNA Repair, the Iannaccone/Walterhouse research group hypothesized that GLI1 competes with the p53 tumor suppressor gene, and sought to determine if this competition has implications. Read the full story.