Research


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Who We Are

The research arm of Lurie Children’s, Stanley Manne Children's Research Institute helps us provide cutting-edge treatments and discover more effective ways to prevent and diagnose conditions that affect children’s health.

Our physicians and scientists are also faculty at Northwestern University Feinberg School of Medicine, our academic partner. Working closely together, our hospital, research institute and medical school train the next generation of pediatric specialists while advancing children's healthcare. 

Learn more about Stanley Manne and his gift.​​​


Read Our Research Blog

The research institute blog, From the Bench, is written by Philip M. Iannaccone, MD, PhD. Dr. Iannaccone's musings range from Mendelian inheritance to exactly how DNA controls human development. Stop by each week to see Dr. Iannaccone's take on research news, myths and surprises.  

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Preventing gestational alloimmune liver disease (GALD)

Gestational alloimmune liver disease (GALD), the most common cause of neonatal hemochromatosis (NH), is a condition that usually results in stillbirth or neonatal death shortly after birth. Peter Whitington, MD, and colleagues are placing a high priority on diagnosing GALD, and preventing it from ever happening.​ Whitington's group has been attacking the problem by comparing normal to GALD liver specimens to find clues. Read the full story.​

Injured hearts and future hope?

In a healthy baby’s heart, two pumping chambers called ventricles sustain life. However, children born with only one ventricle cannot pump blood effectively through their bodies. Conrad Epting, MD is trying to find new ways to help the heart regenerate as an alternative to heart transplantation.​ He and his team study cardiac stem cells. They have found that stem cells exposed to heart failure grow better than those from healthy hearts. Epting hopes that the team's research will offer future therapeutic options. Read more.​

Graduate student investigates control mechanisms for the cystic fibrosis gene 

by Sarah Plumridge, Northwestern University Feinberg School of Medicine News Center

Rui Yang (pictured at left), a student in the Walter S. and Lucienne Driskill Graduate Program at the Feinberg School, uncovered new insights into the structure and expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene that is expressed primarily in epithelial cells, and mutations of which result in cystic fibrosis (CF).​ Yang is a member of the laboratory of Ann Harris, PhD, Professor of Pediatrics at the Feinberg School and director of the Human Molecular Genetics Program​ at the research institute. Read more.