HLA & Immunogenetics

The HLA and Immunogenetics Laboratory was established in 2001 to perform DNA-based tissue typing for the Stem Cell Transplant Program​ at Lurie Children's. We have developed a proprietary, streamlined approach to high resolution testing that enables us to quickly and accurately report allele-level results.

We also routinely resolve all clinically relevant allele ambiguities, which enables our transplant search coordinators to more accurately match transplant recipients with their potential donors. As a result, we are now serving several medical centers as well as international registries. 


Although DNA sequence-based tissue typing and donor engraftment studies are our specialty, we offer a full range of services for hematopoietic and solid organ transplants as well as disease-associated HLA typing, including:

  • HLA low-resolution typing by PCR-SSOP: HLA-A, B, C, DRB1, DQA1, DQB1
  • HLA high-resolution typing by SBT: HLA-A, B, C, DRB1, DQB1
  • Disease-associated HLA typing: B27, B5701, DQ2, DQ8 et al
  • Chimerism analysis by STR
  • HLA antibody screen and specificity by flow cytometry

Laboratory Accreditation

The HLA and Immunogenetics Laboratory meets or exceeds all quality standards set by the industry, and is accredited, registered or licensed by the following organizations to perform high-complexity testing:


DNA-typing can be performed on peripheral blood, bone marrow, cord blood, or buccal brushes. For your convenience, a special collection kit with instructions can be sent directly to recipients or donors.

Contact Us

For questions or to set up service, please call 312.227.6131 or e-mail ljennings@luriechildrens.org