Hematology & Oncology Research

Our multidisciplinary team of physician-scientists conducts various research projects through the Stanley Manne Children's Research Institute​ at Lurie Children's to help promote patient care and better educate families. We hope our research efforts will improve treatment for children with hard-to-treat cancer and blood disorders. View additional information on research studies and researchers below.

Cancer Research

Clinical trials are studies, managed by government agencies, educational institutions, private not-for-profit organizations, or commercial businesses to develop, produce and evaluate the effectiveness of new treatments and therapies for diseases. 

We participate in clinical trials sponsored by:

Blood Disorder Research

We participate in numerous research studies of sickle cell disease and thalassemia, including:

  • A multi-center natural history of iron overload study
  • A multi-institutional, natural history study examining morbidity and risk factors for subsequent strokes in sickle cell disease
  • The Silent Infarct Transfusion Trial (SITT) to determine the benefit of chronic transfusion therapy in sickle cell patients with silent strokes
  • A randomized multi-center trial comparing hydroxyurea to chronic transfusions in preventing secondary strokes in sickle cell patients (SWiTCH)
  • Industry-sponsored, multi-institutional studies examining the safety and efficacy of a new iron chelator on transfusion related iron overload
  • Study screening for pulmonary hypertension and its effects in children and adolescents with sickle cell disease, a complication associated with a high risk of mortality in early adulthood
  • Translational research initiative in sickle cell disease to validate a computer-based pain and genetic profiling of markers for opioid responsiveness
  • Use of MRI for noninvasive iron assessments in thalassemia and sickle cell disease
  • Cardiopulmonary impairment in children with sickle cell disease and evaluation of exercise capacity in sickle cell disease
  • Program evaluating the utility of a multidisciplinary, educational approach to transitioning adolescents to an adult centered sickle cell program 

Clinical Studies