Hematology & Oncology Research
Our multidisciplinary team of physician-scientists conducts various research projects to help promote patient care and better educate families. We hope our research efforts will improve treatment for children with hard-to-treat cancer and blood disorders. View additional information on research studies and researchers below.
Clinical trials are studies, managed by government agencies, educational institutions, private not-for-profit organizations, or commercial businesses to develop, produce and evaluate the effectiveness of new treatments and therapies for diseases.
We participate in clinical trials sponsored by:
Blood Disorder Research
We participate in numerous research studies of sickle cell disease and thalassemia, including:
- A multi-center natural history of iron overload study
- A multi-institutional, natural history study examining morbidity and risk factors for subsequent strokes in sickle cell disease
- The Silent Infarct Transfusion Trial (SITT) to determine the benefit of chronic transfusion therapy in sickle cell patients with silent strokes
- A randomized multi-center trial comparing hydroxyurea to chronic transfusions in preventing secondary strokes in sickle cell patients (SWiTCH)
- Industry-sponsored, multi-institutional studies examining the safety and efficacy of a new iron chelator on transfusion related iron overload
- Study screening for pulmonary hypertension and its effects in children and adolescents with sickle cell disease, a complication associated with a high risk of mortality in early adulthood
- Translational research initiative in sickle cell disease to validate a computer-based pain and genetic profiling of markers for opioid responsiveness
- Use of MRI for noninvasive iron assessments in thalassemia and sickle cell disease
- Cardiopulmonary impairment in children with sickle cell disease and evaluation of exercise capacity in sickle cell disease
- Program evaluating the utility of a multidisciplinary, educational approach to transitioning adolescents to an adult centered sickle cell program