Remission in Pediatric Epilepsy

Epilepsy is one of the most common neurological disorders, affecting 2.5 million Americans. Each year, over 180,000 new cases are diagnosed. Clinical research to help those patients who have shown resistance to antiepileptic drugs (AEDs) has not changed significantly in 50 years.

In 1951 it was reported that 25% of children with epilepsy could not be adequately controlled. Today, after 50 years of epilepsy research, the percent of children with inadequately controlled epilepsy has improved to only 23%. As a result, neurologists today are unable to help patients diagnosed with epilepsy any better than neurologists 50 years ago. And in 1951, there were a limited number of AEDs — today there are over 50 antiepileptic drugs available.

This study aims to collect similar and consistent data on epilepsy patients from multiple epilepsy centers and then categorize the data in a similar fashion. The multi-site study will include Douglas Nordli, MD, William Galliard, MD, at National Children’s Hospital, Washington, D.C., and Helen Cross, MD, PhD, at Great Ormond Street Hospital for Children, London, U.K. Data will be collected from medical charts at each site and de-identified prior to entry onto a secure web-based database designed and maintained by Malek Adjouadi, PhD, at Florida International University.

It is hoped that by collecting and sharing the histories of a large number of children with epilepsy, treatment for those with hard to treat epilepsies can be improved.