Mary Beth Madonna, MD

Attending Physician, Pediatric Surgery; Associate Professor of Surgery, Northwestern University Feinberg School of Medicine

Special Interests

Pediatric surgery, minimally invasive surgery, congenital and acquired malformations, bowel and intestinal disease, anorectal malformations, hernia, pediatric endocrine tumors, neck masses, gynecologic disease, cancer surgery, disorder of sexual development

Research Interests

Neuroblastoma, drug resistance

Biographical Information

Medical School

Finch University/Chicago Medical School, 1988

Postgraduate Training

Fellowship in pediatric surgery, Northwestern McGaw/Children’s Memorial Hospital (currently Ann & Robert H. Lurie Children’s Hospital of Chicago), 1996-2000; Residency in general surgery, University of Illinois Metropolitan Group Hospitals, 1988-1993


Board certified in: Pediatric Surgery

Additional Information

​Dr. Madonna is one of the nation’s leading experts on bowel and intestinal disease and pediatric endocrine tumors.

She is a pediatric surgeon specializing in the treatment of a wide variety of congenital and acquired malformations in infants, children and adolescents including intestinal diseases and anorectal malformations, hernia, gynecologic diseases, neck masses and cancer surgery among others.

Dr. Madonna is the founder and director of Lurie Children’s specialized, multidisciplinary bowel management clinic for patients with a variety of intestinal diseases and spinal cord anomalies — one of the first clinics of this kind in the United States. The clinic offers a three-pronged approach to the treatment and care of children with fecal continence problems and includes a week-long intensive program, a continuity clinic and a combined clinic with a motility specialist from the Department of Gastroenterology. In addition, the clinic focuses on management that goes well beyond traditional medication and also addresses the social, psychological and emotional needs of patients.

Dr. Madonna is also a leader in the surgical care of children with disorders of sexual development and part of Lurie Children’s multidisciplinary program, which includes specialists from urology, endocrinology and psychology.

As a physician-scientist, Dr. Madonna has focused on unraveling the mechanisms of tumor drug resistance — how cancer cells adapt to evade and survive chemotherapy — with special focus on neuroblastoma, a pediatric tumor that arises from the adrenal glands. Ongoing investigation — both in lab and in clinic — by Dr. Madonna and collaborators can help pave the way toward individualized treatment of children with this type of cancer by profiling the genetic makeup of their tumors to study it for traits of possible resistance and develop tailored therapies.

To learn more about Dr. Madonna’s research, visit


Procedures Performed

Congenital Abnormalities

  • Intestinal atresia
  • Congenital diaphragmatic hernia
  • Gastroschisis and omphalocele (abdominal wall defects)
  • Tracheo-esophageal Fistula
  • Chest and abdominal masses
  • Imperforate anus

Esophageal and alimentary tract surgeries

  • Esophageal duplication or masses
  • Nissen fundoplication
  • Gastric tubes (G-tubes)
  • Bowel resection for inflammatory bowel disease (Ulcerative Colitis, Crohn’s disease)
  • Hirschsprung’s disease
  • Malrotation of the intestinal tract
  • Liver and pancreatic surgery
  • Cholecystectomy
  • Splenic Surgery (complete and partial for cysts, sickle cell disease, idiopathic thrombocytopenia purpura)
  • Appendicitis

Abdominal Tumors

  • Neuroblastoma
  • Wilms' Tumor
  • Mesenteric cyst and mesenteric tumor resection
  • Ovarian Masses

Chest Surgeries

  • Thorascospic phrenic nerve pacing
  • Lung masses (CPAM, lung metastases)
  • Chest and mediastinal masses
  • Recurrent pneumothorax
  • Rib lesions

Endocrine surgery

  • Adrenal
  • Thyroid
  • Pancreatic

Gynecologic surgery

  • Ovary cyst or torsion (ovarian sparing or oophorectomy)
  • Pelvic cyst
  • Hematometrocolpos

Congenital neck cyst excision and drainage

  • Branchial cyst
  • Thyroglossal duct


Lymph node biopsy and excision

Breast surgery

Soft Tissue Masses

Vascular malformations

Inguinal, umbilical, epigastric and incisional hernias

Undescended Testicles

Muscle biopsies


View Dr. Madonna's Pub Med Link
View Dr. Madonna's Northwestern University Faculty Profile
View Dr. Madonna's Northwestern Scholars Profile