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Retinopathy of Prematurity

Retinopathy of prematurity (ROP) is a disorder of the blood vessels of the retina (the light sensitive part of the eye). ROP is most common in premature babies. Generally, the more premature the baby and the lower the birthweight, the greater the risk for developing ROP.

The exact mechanism of ROP is not fully understood. The retina is the thin layer of light-sensitive nerve fibers and cells that covers the inside and back of the eye. In a premature baby, the central retina is established but the peripheral retina and its blood vessels are not completely developed until the baby reaches full term. The blood vessels may develop abnormally as they grow due in part to excessive growth factors being produced by the undeveloped retina. The abnormal growth of the vessels may lead to bleeding, scarring and retinal detachment. These problems may result in severe vision loss.

There are five stages of ROP, from a mild Stage 1 to severe Stage 5 when the retina completely detaches in the eye. Fortunately, about 90% of babies with Stage 1 and 2 ROP show improvement without treatment. However, about half of babies with Stage 3 and most of those with Stage 4 may develop serious eye damage. Each year, approximately 400 to 600 children are blinded by ROP.


In 2001, the American Academy of Pediatrics (AAP) and the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) updated recommendations for babies at risk for ROP. These guidelines include the following:

  • Eye examination, by a qualified ophthalmologist, for low birthweight and/or premature babies who are at risk for ROP
  • Eye examination should be done at 4 to 6 weeks of age, or when the baby reaches 31 to 33 weeks gestational age
  • Follow-up eye examinations at appropriate times
  • Considering babies with severe categories of ROP for treatment within 24 hours of diagnosis


Early diagnosis of damage is important in the treatment of ROP. Babies who develop severe ROP may benefit from a laser photocoagulation treatment to the retina to induce regression of abnormal blood vessels and to prevent further damage from occurring. The laser treatment involves placing laser spots on the peripheral undeveloped retina. This stops the undeveloped retina from producing the excessive growth factors that promote the retinopathy. Although this treatment is successful for the majority of patients, a few patients may not do well and may still need further surgery. Even with successful surgery, the baby will need to have continued care with a pediatric ophthalmologist.

Make an Appointment

If you’d like to request an appointment with one of our specialists from the Division of Ophthalmology, call 1.800.543.7362 (1.800.KIDS DOC®). You can also request an appointment online.


Related Specialties & Services

Read about the specialty areas and services that treat Retinopathy of Prematurity.